HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Methoxy-4-methylpyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-methoxy-4-methylpyridin-3-ylcarbamate | HCID 10082908 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Methoxy-4-methylpyridin-3-amine | HCID 10329361 | 100% |
Reaction Steps
3-(tert-Butoxycarbonylamino)-2-methoxy-4-methylpyridine (0.7 g, 2.9 mmol) was treated with 25 mL of 4M HCl in EtOAc at room temperature overnight. The resulting suspension was carefully washed with sat. NaHCO3, dried (MgSO4) and concentrated to give 0.4 g of the free amine as an oil (100%). m.p. (HCl salt): 199° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05532358 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-9ff4367edf7e4ff59a9646f0405f517f |
| Source note | uspto-grants-1996_07 |