HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1734142Generated: October 30, 2026
Dimethylformamide → 2-[(Oxolan-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
https://huagongshe.com/reaction/1734142
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester | HCID 15335290 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[(Oxolan-3-yl)methyl]-1H-isoindole-1,3(2H)-dione | HCID 22399030 | 99.8% |
Reaction Steps
A mixture comprising 30.0 g of (tetrahydro-3-furanyl)methyl tosylate, 23.0 g of potassium phthalimide and 150 ml of DMF was stirred at 80° C. for 8 hours. Water was poured into the reaction mixture, and crystals precipitated out was separated by filtration to obtain 27.0 g of N-{(tetrahydro-3-furanyl)methyl}phthalimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05532365 |
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| Source dataset | uspto-grants-1996_07 |
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| ORD ID | ord-91ad557b73c7456cbbade5a328233040 |
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| Source note | uspto-grants-1996_07 |
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