HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Amino-2-cyano-6-(trimethylsilylethynyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 3-Amino-2-cyano-6-iodopyridine | HCID 19040785 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Amino-2-cyano-6-(trimethylsilylethynyl)pyridine | HCID 19040787 | — |
Reaction Steps
This compound is prepared in a manner analogous to that of Step A of Example 9, using 3.8 grams (0,015 mole) of 3-amino-2-cyano-6-iodopyridine (prepared in Step A of Example 10), 2.1 grams (0.021 mole) of trimethylsilylacetylene, 10.6 mL of triethylamine, 0.13 gram of copper iodide, and 0.29 gram of bis(triphenylphosphine)palladium(II) chloride in 50 mL of acetonitrile, yielding 3-amino-2-cyano-6-(trimethylsilylethynyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05532367 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-ea585f1f53c3462995659d7176cba6d5 |
| Source note | uspto-grants-1996_07 |