反应详情

3.0 g (0,014 mol) of 1-benzyl-6-aminouracil are stirred for 3 hours at 70° C. with 2.2 g (0.018 mol) of n-propyl bromide, 4.2 ml of 15% sodium hydroxide solution and 7 ml of ethanol. The mixture is poured onto ice and extracted with methylene chloride. The organic phases are dried and evaporated down. The residual oil is crystallised from a mixture of methylene chloride and methanol. 1.62 g of the title compound are obtained in the form of white crystals (47% of theory), m.p. 189°-192° C.

1. additionThe mixture is poured onto ice
2. extractionextracted with methylene chloride
3. customThe organic phases are dried
4. customevaporated down
5. customThe residual oil is crystallised from a mixture of methylene chloride and methanol