HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamide, N-(4-fluoro-3-nitrophenyl)- → 6-Methylthio-3-acetylaminonitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamide, N-(4-fluoro-3-nitrophenyl)- | HCID 67694 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 6-Methylthio-3-acetylaminonitrobenzene | HCID 22908359 | — |
Reaction Steps
At room temperature, 50.0 g of sodium thiomethoxide are suspended in 500 ml of dimethoxyethane and 99.1 g (0.5 mole) of 2-nitro-4-acetylaminofluorobenzene are added, in portions, over 30 min, while the temperature is maintained between 25° and 27° C. by means of an ice cold water bath.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05534037 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-a6682bc0e8a440a6b4ff07695b27501a |
| Source note | uspto-grants-1996_07 |