Sulfuric Acid → HCID 12011882, compound

HRID 1734397Notes

Reaction equation

Br[C:2]1[C:6]([N+:7]([O-])=O)=[C:5]([NH:10][CH3:11])[N:4]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:3]=1.S(=O)(=O)(O)O>>[NH2:7][C:6]1[CH:2]=[N:3][N:4]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[C:5]=1[NH:10][CH3:11]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 19437616HCID 19437616, compound

Product 1

HCID 12011882HCID 12011882, compoundYield 87%

Procedure

1.04 g (3.00) mmoles) of 3-bromo-1 -(4'-methoxybenzyl)-5-methylamino-4-nitropyrazole are hydrogenated for 2 hours according to General Directions A. 0.30 g (2.80 mmoles) of concentrated sulfuric acid (97%) are added. After reduction, 0.86 g (87 percent of theory) of 4-amino-1-(4'-methoxybenzyl)-5-methylaminopyrazole hydrosulfate are obtained in the form of an oil.

Sources & evidence

ORD record: ord-5b1206a7893b44fe80d2c747d7912d1f
Source dataset: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05534267

Reaction notes

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