Ethanethiol → HCID 19083168, compound

HRID 1734417Notes

Reaction equation

HRID 1734417 reaction equation
[CH2:1]([SH:3])[CH3:2].CC(C)([O-])C.[K+].F[C:11]1[C:12]2[C:16]([CH:17]=[CH:18][CH:19]=1)=[N:15][N:14]([CH3:20])[C:13]=2[S:21]([NH2:24])(=[O:23])=[O:22]>CS(C)=O>[CH2:1]([S:3][C:11]1[C:12]2[C:16]([CH:17]=[CH:18][CH:19]=1)=[N:15][N:14]([CH3:20])[C:13]=2[S:21]([NH2:24])(=[O:23])=[O:22])[CH3:2]

Participants

5

Reactant 3

HCID 6343EthanethiolHCID 190831614-fluoro-2-methyl-2H-indazole-3-sulfonamideHCID 23665647Potassium tert-butoxide

Product 1

HCID 19083168HCID 19083168, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

4.8 g (77 mmol) of ethanethiol was added to a solution containing 8.6 g (77 mmol) of potassium t-butoxide in DMSO (70 ml), under cooling with ice, and 8 g (35 mmol) of 4-fluoro-2-methyl-2H-indazole-3-sulfonamide was further added thereto. This mixture was stirred at 120° C. for 2 hours. After confirming the disappearance of the starting material by TLC, treatment was conducted in the same manner as in Preparation Example 6 to obtain 6.8 g (yield: 72.5%) of the desired product. Melting: 145°-147° C.

Workup

  1. additionwas further added
  2. customwas conducted in the same manner as in Preparation Example 6

Sources & evidence

ORD record
ord-131f7f2b01aa41f2ac6793c456856586
Source dataset
uspto-grants-1996_07
Patent number
US05534481

Reaction notes

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