Sodium borohydride → 1-Benzyl-7-benzylamino-3-hydroxymethyl-2-methylpyrrolo[2,3-d]pyridazine

HRID 1734518Notes

Reaction equation

HRID 1734518 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:14]=[N:15][CH:16]=[C:11]2[C:10]([CH:25]=[O:26])=[C:9]1[CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([N:8]1[C:12]2=[C:13]([NH:17][CH2:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:14]=[N:15][CH:16]=[C:11]2[C:10]([CH2:25][OH:26])=[C:9]1[CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 194377411-Benzyl-7-benzylamino-3-formyl-2-methylpyrrolo[2,3-d]pyridazine

Product 1

HCID 194377631-Benzyl-7-benzylamino-3-hydroxymethyl-2-methylpyrrolo[2,3-d]pyridazineYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.2 g (0.56 mmol) of 1-benzyl-7-benzylamino-3-formyl-2-methylpyrrolo[2,3-d]pyridazine and 23 mg (0.62 mmol) of sodium borohydride are reacted in 20 ml of methanol as described for Example 1a. Yield: 80%, m.p.: 238°-240° C.

Sources & evidence

ORD record
ord-14fb46d2b6f9429cb8539480a84889a9
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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