HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Benzyl-7-benzyloxy-3-formyl-2-methylpyrrolo[2,3-d]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Benzyl-7-benzyloxy-3-bromo-2-methylpyrrolo[2,3-d]pyridazine | HCID 19437764 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-Benzyl-7-benzyloxy-3-formyl-2-methylpyrrolo[2,3-d]pyridazine | HCID 19437754 | 32% |
Reaction Steps
5.0 g (12.2 mmol) of 1-benzyl-7-benzyloxy-3-bromo-2-methylpyrrolo[2,3-d]pyridazine, 9 ml (14.7 mmol) of a 15% strength solution of n-butyllithium in hexane and 2.4 ml (29.4 mmol) of dimethylformamide are reacted in 125 ml of anhydrous tetrahydrofuran as described for Example 2a. Yield: 32%, m.p.: 147°-149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05534515 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-b311959ca3774da79a2e13d262136ed4 |
| Source note | uspto-grants-1996_07 |