Bromine → HCID 19437752, compound

HRID 1734524Notes

Reaction equation

HRID 1734524 reaction equation
[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[CH:17]=[C:16]([CH3:18])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:14]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:28]Br>ClCCl>[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[C:17]([Br:28])=[C:16]([CH3:18])[N:15]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=3)[C:14]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 19437769HCID 19437769, compound

Product 1

HCID 19437752HCID 19437752, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.8 g (5 mmol) of 7-benzyloxy-l-(4-methoxybenzyl)-2-methylpyrrolo[2,3-d]pyridazine and 282 μl (5.5 mmol) of bromine are reacted in a total of 65 ml of dichloromethane and purified as described for Example 3a. Yield: 78%, m.p.: 149°-152° C.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-2e907c777a814ad5a6da7e2954dde1bd
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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