Acetic Anhydride → HCID 15291737, compound

HRID 1734570Notes

Reaction equation

HRID 1734570 reaction equation
[NH2:1][CH2:2][C:3]1([OH:10])[CH2:8][CH2:7][N:6]([CH3:9])[CH2:5][CH2:4]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(Cl)(Cl)Cl>[C:11]([NH:1][CH2:2][C:3]1([OH:10])[CH2:8][CH2:7][N:6]([CH3:9])[CH2:5][CH2:4]1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 64842624-(Aminomethyl)-1-methylpiperidin-4-ol

Product 1

HCID 15291737HCID 15291737, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4-Aminomethyl-4-hydroxy-1-methylpiperidine (0.83 g., 5.7 mmole) was dissolved in 10 ml. chloroform, and acetic anhydride (0.58 g., 5.7 mmole) was added. The reaction mixture warmed spontaneously to 40°-50° C. After 30 minutes, the solvent was evaporated and the crude residue was chromatographed on a silica gel column (Merck 7734), using 33:67 2% aqueous ammonia-methanol as eluent.

Workup

  1. temperatureThe reaction mixture warmed spontaneously to 40°-50° C
  2. customthe solvent was evaporated
  3. customthe crude residue was chromatographed on a silica gel column (Merck 7734)

Sources & evidence

ORD record
ord-45017ee5449d453d804ade43d2b6af1c
Source dataset
uspto-grants-1996_07
Patent number
US05534520

Reaction notes

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