Water → HCID 19437941, compound

HRID 1734571Notes

Reaction equation

HRID 1734571 reaction equation
Br.[Cl:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([NH2:7])=[NH:6].[Cl:12][C:13](Cl)(Cl)[S:14]Cl.[OH-].[Na+].O>ClCCl>[Cl:12][C:13]1[S:14][N:7]=[C:5]([C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[Cl:2])[N:6]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11666Trichloromethanesulfenyl chlorideHCID 14798Sodium HydroxideHCID 19437937HCID 19437937, compound

Product 1

HCID 19437941HCID 19437941, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
-10 °C

Procedure

To a mixture of 37 g of 2-chlorobenzamidine hydrobromide in 160 ml of dichloromethane, cooled to -10° C., are added dropwise 36 g of trichloromethanesulphenyl chloride dissolved in 160 ml of dichloromethane. After stirring for 30 min, 65 ml of aqueous 50% NaOH solution are added dropwise to the medium, still at -10° C. The solution is allowed to return to room temperature and is stirred for 2 h. Water is added to the reaction medium and the phases are separated after settling has taken place. The organic phase is washed with water, dried over sodium sulphate and evaporated to dryness.

Workup

  1. customto return to room temperature
  2. stirringis stirred for 2 h
  3. customthe phases are separated after settling
  4. washThe organic phase is washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-3ee064f4635547b9abf3d52a877842a9
Source dataset
uspto-grants-1996_07
Patent number
US05534530

Reaction notes

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