2,4,6-Trimethoxybenzonitrile → N-HYDROXY-2,4,6-TRIMETHOXY-BENZAMIDINE

Participants

Reaction Steps

To a suspension of 13.8 g of hydroxylamine hydrochloride in 100 ml of ethanol is added, at a temperature in the region of 15° C., a solution of NaOC2H5 prepared by dissolving 4.3 g of sodium in 100 ml of ethanol. 12 g of 2,4,6-trimethoxybenzonitrile are introduced into the medium, followed by heating at reflux for 41 h before evaporating to dryness. The crystals are washed with water and with dichloromethane.

Provenance & Evidence