N-HYDROXY-2,4,6-TRIMETHOXY-BENZAMIDINE → 2,4,6-Trimethoxy-benzamidine

Participants

Reaction Steps

3.4 g of 2,4,6-trimethoxybenzamidoxime are dissolved in 120 ml of a methanol/dichloromethane/acetic acid mixture (2/2/1; (v/v/v)) in an autoclave and hydrogenation is carried out at a pressure of 2×106Pa in the presence of 1 g of Raney nickel. After hydrogenation for 2 hours, the catalyst is separated out and the mixture is concentrated to dryness.

Provenance & Evidence