HRID1734626

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

结构：COC(=O)c1ccc(OCCCOc2c(C)c(C)c(C(=O)Oc3c(C)c(C)c(C(N)=O)c(OC)c3C)c(OC)c2C)cc1

HCID19437957

未命名化合物

PRODUCTS

生成物

结构：COc1c(C)c(OC(=O)c2c(C)c(C)c(OCCCOc3ccc(C(=O)O)cc3)c(C)c2OC)c(C)c(C)c1C(N)=O

HCID9873033

未命名化合物

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

To a solution of the amide-ester prepared in Example 46 (101, 694 mg, 1.17 mmol) in 30 ml of DMSO, was added 1N-KOH (3.5 ml, 3.5 mmol) with stirring, so that the amide-ester was subjected to hydrolysis to give 602 mg of the title compound 102 (89%).

WORKUP

后处理

customwas subjected to hydrolysis

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e08cee55edbd4ec3ba14cabfcd41c729
来源数据集: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05534533
来源说明: uspto-grants-1996_07

反应 SMILES

C[O:2][C:3]([C:5]1[CH:43]=[CH:42][C:8]([O:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[C:36]([CH3:37])=[C:35]([CH3:38])[C:17]([C:18]([O:20][C:21]3[C:29]([CH3:30])=[C:28]([CH3:31])[C:24]([C:25]([NH2:27])=[O:26])=[C:23]([O:32][CH3:33])[C:22]=3[CH3:34])=[O:19])=[C:16]([O:39][CH3:40])[C:15]=2[CH3:41])=[CH:7][CH:6]=1)=[O:4].[OH-].[K+]>CS(C)=O>[C:3]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[C:36]([CH3:37])=[C:35]([CH3:38])[C:17]([C:18]([O:20][C:21]3[C:29]([CH3:30])=[C:28]([CH3:31])[C:24]([C:25]([NH2:27])=[O:26])=[C:23]([O:32][CH3:33])[C:22]=3[CH3:34])=[O:19])=[C:16]([O:39][CH3:40])[C:15]=2[CH3:41])=[CH:42][CH:43]=1)([OH:4])=[O:2]