HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 1-Butanone, 2-(dimethylamino)-1-(4-(dimethylamino)phenyl)-2-(phenylmethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Benzyl-2-(dimethylamino)-1-(4-fluorophenyl)butan-1-one | HCID 19360599 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Butanone, 2-(dimethylamino)-1-(4-(dimethylamino)phenyl)-2-(phenylmethyl)- | HCID 164106 | — |
Reaction Steps
A stirred autoclave is filled with 50 g (0.167 mol) of 1-(4-fluorophenyl)-2-dimethylamino-2-benzylbutan-1-one (crude produce from B), 300 ml of dimethylformamide and 23.1 g (0.167 mol) of potassium carbonate. 22.6 (0.5 mol) of dimethylamine are then added under pressure (3-4 bar). The mixture is heated to 100° and stirred at this temperature for 24 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05534629 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-f3ecf55582bd446bb7309eaa2739019b |
| Source note | uspto-grants-1996_07 |