Pyridine → HCID 19438397, compound

Participants

Reaction Conditions

Reaction Steps

2.53 g (10 mmole) of 4-ethoxycarbonyl-1-methylpyrazole-5-sulfonylchloride was dissolved in 10.00 g of anhydrous acetonitrile. To the resulting solution was added dropwise 0.83 g (10.5 mmole) of dry pyridine over 5 minutes under nitrogen atmosphere by means of a syringe and the mixture was maintained at 40° C. To this mixture was added 0.72 g (11.0 mmole) of anhydrous sodium cyanate and the mixture was stirred while maintaining the temperature of 40° to 45° C. to complete the reaction. Then, the reaction mixture was treated according to the same procedure as Example 5 to obtain 3.50 g (Yield 90%) of the title compound as the white solid substance.

Provenance & Evidence