N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamide → N-[2-t-Butyl-5-(4-cyclohexyl-1-hydroxybutyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

HRID 1734866Notes

Reaction equation

HRID 1734866 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][Mg]I)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:12]([C:16]1[CH:21]=[CH:20][C:19]([CH:22]=[O:23])=[CH:18][C:17]=1[NH:24][C:25](=[O:41])[CH2:26][CH:27]1[C:40]2[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=2[O:34][C:33]2[C:28]1=[CH:29][CH:30]=[CH:31][CH:32]=2)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([C:16]1[CH:21]=[CH:20][C:19]([CH:22]([OH:23])[CH2:9][CH2:8][CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:18][C:17]=1[NH:24][C:25](=[O:41])[CH2:26][CH:27]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:33]=2[O:34][C:35]2[C:40]1=[CH:39][CH:38]=[CH:37][CH:36]=2)([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 19966116N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamideHCID 178506591HCID 178506591, compound

Product 1

HCID 19966299N-[2-t-Butyl-5-(4-cyclohexyl-1-hydroxybutyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

Procedure

Following a procedure similar to that described in Example 14, but using 3-cyclohexylpropylmagnesium iodide and N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamide (prepared as described in Preparation 15) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a foam-like substance.

Sources & evidence

ORD record
ord-b337b221a34f454c881f5c505b99a4a0
Source dataset
uspto-grants-1996_07
Patent number
US05534529

Reaction notes

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