反应详情

N-[2-(Indolin-1-yl)phenyl]-dimethylaminocarboxamide (37 gm; 0.13 moles) in acetic anhydride (140 ml) was refluxed for 30 minutes. The mixture was cooled to ~50° C., and thereafter concentrated on a rotary evaporator to about 80 ml while crystallization occurred. The red solid was filtered and washed with ether. Recrystallization from chloroform (500 ml) afforded red-orange crystals: 21.3 gm (68%), m.p. 213.5°-214.5° C.

1. temperatureThe mixture was cooled to ~50° C.
2. concentrationconcentrated on a rotary evaporator to about 80 ml while crystallization
3. filtrationThe red solid was filtered
4. washwashed with ether
5. customRecrystallization from chloroform (500 ml)
6. customafforded red-orange crystals