(3-Aminopyrazin-2-yl)methanol → 3-Aminopyrazine-2-carbaldehyde

HRID 1735048Notes

Reaction equation

HRID 1735048 reaction equation
[NH2:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][N:7]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[C:3]([CH:8]=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 1

HCID 33728543(3-Aminopyrazin-2-yl)methanol

Product 1

HCID 152749313-Aminopyrazine-2-carbaldehydeYield 82%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A suspension of 3-aminopyrazine methanol, 6.3 g (0.05 mol) and manganese dioxide (38.0 g) in 400 mL of chloroform is stirred at room temperature for two hours and the resulting solid is filtered off. The filtrate is evaporated to dryness which gives the desired product as a yellow crystalline solid, (5.00g, 82% yield) having a melting point 110°-114° C.

Workup

  1. filtrationthe resulting solid is filtered off
  2. customThe filtrate is evaporated to dryness which

Sources & evidence

ORD record
ord-bece8be05d7f41588a2bb1b9ad94b67f
Source dataset
uspto-grants-1996_07
Patent number
US05536702

Reaction notes

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