HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Methyl-2,4,6-trichloroindole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Methyl-4,6-dichloro-1,3-dihydroindol-2-one | HCID 19068987 | — |
| Product | 1-Methyl-2,4,6-trichloroindole-3-carbaldehyde | HCID 19068978 | — |
Reaction Steps
Prepared from POCl3 (11 ml), DMF (11 ml), (43) (8.4 g), yielding (48) 6.5 g as crude product sufficiently pure for the next synthesis. 1H-NMR (DMSO-d6): δ3.8 (s, 3H), 7.43 (d, 1H), 7.86 (d, 1H), 10.52 (s, 1H). In this reaction the reaction time was 24 h instead of 3 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536721 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-fb75c43ee94d4565b54e03135b4a3711 |
| Source note | uspto-grants-1996_07 |