HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4,6-dichloro-8-methylthieno[2,3-b]indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | 1-Methyl-2,4,6-trichloroindole-3-carbaldehyde | HCID 19068978 | — |
| Product | Methyl 4,6-dichloro-8-methylthieno[2,3-b]indole-2-carboxylate | HCID 19068958 | 32.5% |
Reaction Steps
Prepared from (48) (6.5 g), K2CO3 (9.59 g) and methyl 2-mercaptoacetate (3.82 ml) yielding (53) 2.5 g (32.5%). M.p. 231°-232° C. The product was purified by chromatography on silicagel using toluene as eluent. The compound was crystallized by trituration with methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536721 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-4b89d86682534f22bc83d73ee4045610 |
| Source note | uspto-grants-1996_07 |