HCID 67604977, compound → HCID 67605181, compound

HRID 1735113Notes

Reaction equation

HRID 1735113 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]3[C:13]([CH3:14])=[CH:12][S:11][C:10]=13)[NH:7][C:6]([C:15]([O:17]C)=[O:16])=[CH:5]2>[OH-].[Na+].CO.O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]3[C:13]([CH3:14])=[CH:12][S:11][C:10]=13)[NH:7][C:6]([C:15]([OH:17])=[O:16])=[CH:5]2

Participants

4

Reactant 1

HCID 67604977HCID 67604977, compound

Product 1

HCID 67605181HCID 67605181, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 22242641Methanol--water (1/1)Solvent

Procedure

2.5 g of (70) was hydrolyzed during 3 hours at reflux in a mixture of 25 ml 4 N NaOH and 100 ml MeOH/water 1+1. After cooling to room temperature and acidification with acetic acid the product precipitated. Filtration and drying gave 2.4 g of (71). M.p. 229°-41° C.

Workup

  1. customacidification with acetic acid the product precipitated
  2. filtrationFiltration
  3. customdrying

Sources & evidence

ORD record
ord-aefefee05b994d8285219b2559039d66
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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