HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Acetyl-2-chloro-1-methylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(2-Chloro-1H-indol-3-yl)ethan-1-one | HCID 10932307 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Acetyl-2-chloro-1-methylindole | HCID 820344 | — |
Reaction Steps
To a slurry of 310 mg of NaH in 15 ml THF was added 1 g of (75), and then 625 μl of methyl iodide. The reaction was left with stirring for 3 days. Water was added, the product extracted with diethylether, and the ether phase dried and evaporated to dryness to give (76). Yield 870 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536721 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-1a1b03e661844938bcd173df2cdaf05b |
| Source note | uspto-grants-1996_07 |