Sodium Carbonate → HCID 19436843, compound

HRID 1735128Notes

Reaction equation

HRID 1735128 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4](Cl)[N:3]=1.C(=O)([O-])[O-].[Na+].[Na+].O1CCOCC1.Cl.[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][C:34]=1[O:35][CH3:36])[CH2:31][NH:30][CH2:29][CH2:28]2>O>[Cl:8][C:6]1[N:5]=[C:4]([N:30]2[CH2:29][CH2:28][C:27]3[C:32](=[CH:33][C:34]([O:35][CH3:36])=[C:25]([O:24][CH3:23])[CH:26]=3)[CH2:31]2)[N:3]=[C:2]([NH2:1])[N:7]=1

Participants

6

Reactant 4

HCID 10340Sodium CarbonateHCID 136154,6-Dichloro-1,3,5-trazin-2-amineHCID 312751,4-DioxaneHCID 64560356,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Product 1

HCID 19436843HCID 19436843, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-amino-4,6-dichloro-1,3,5-triazine (9.7 g, 58.8 mM) was dispersed in water (50 mL), sodium carbonate solution (2N, 60 mL) and dioxane 15 mL) at 0° C. 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (13.9 g, 58.8 mM) was added and the mixture was stirred vigorously for 1 hr. The product was filtered, rinsed with water, dried and recrystallized from methanol; 14.3 g (75%), mp=196°-197° C.

Workup

  1. customat 0° C
  2. filtrationThe product was filtered
  3. washrinsed with water
  4. customdried
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-54d88243a5804512973041f305770c73
Source dataset
uspto-grants-1996_07
Patent number
US05536722

Reaction notes

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