Hydrochloric Acid → N-[(1,2,3,4-tetrahydroacridin-9-yl)aminocarbonylmethyl]-L-alanine

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Reaction Steps

Into 12 ml of 1N aqueous solution of sodium hydroxide, was added 2 g of the compound obtained in Example 38 at room temperature, and the reaction was continued for 2 hours. To the reaction mixture, was added 15 ml of 1N hydrochloric acid at a temperature not higher than 15° C. to precipitate white crystals. The crystals were collected by filtration, washed with water and dried to obtain 1.42 g of the titled compound having the melting point of 238° to 242° C. (decomposed).

Provenance & Evidence