HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178444424, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-Bromo-4-(trifluoromethoxy)benzene | HCID 521008 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 178444481 | HCID 178444481 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Zinc bromide | HCID 10421208 | — |
| Solvent | Tetrahydrofuran toluene | HCID 22635083 | — |
| Product | HCID 178444424 | HCID 178444424 | — |
Reaction Steps
0.7 g of lithium and 5.7 g of ZnBr2 are added at 0° to a mixture of 15.4 g of trans-4-pentylcyclohexylethyliodide and 100 ml of THF/toluene (1:4), and the reaction mixture is treated with ultrasound at 0°-10° for 4 hours. 14.8 g of 4-trifluoromethoxybromobenzene and 0.88 g of PdCl2 (dppf) are subsequently added at 5°. The mixture is allowed to warm to room temperature and is stirred for a further 16 hours. The mixture is then poured into 100 ml of saturated NH4Cl solution, and the organic phase is worked up. After purification by chromatography and/or crystallization, 1-(4-trifluoromethoxyphenyl)-2-(trans-4-pentylcyclohexyl)-ethane is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536442 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-5b268abe468840c8b648850146230b32 |
| Source note | uspto-grants-1996_07 |