HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Difluoromethoxy-(5-propyl-1,3-dioxan-2-yl)-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | p-(Difluoromethoxy)benzaldehyde | HCID 2736986 | — |
| Reactant | Pentane-3,3-diol | HCID 21837878 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Difluoromethoxy-(5-propyl-1,3-dioxan-2-yl)-benzene | HCID 19436343 | — |
Reaction Steps
17.2 g of p-difluoromethoxybenzaldehyde (commercially available from Fluorochem. Ltd. (GB)), 10.4 g of ethylpropanediol and 0.2 g of p-TsOH are heated to boiling for 2 hours in 100 ml of toluene. After evaporation of the solvent, the mixture is worked up as usual.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536442 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-43608c7d2d994831902b3a77d9c29441 |
| Source note | uspto-grants-1996_07 |