HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1735374Generated: October 30, 2026
4-Bromophenol → 1-(4-Ethoxyphenyl)-2-(4'-difluoromethoxyphenyl)-ethene
https://huagongshe.com/reaction/1735374
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | 4-Ethoxystyrene | HCID 79570 | — |
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | 1-Bromo-4-(difluoromethoxy)benzene | HCID 2737007 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(4-Ethoxyphenyl)-2-(4'-difluoromethoxyphenyl)-ethene | HCID 54057516 | — |
Reaction Steps
22.2 g of 4-ethoxystyrene, 33-5 g of 4-(difluoromethoxy)bromobenzene (available from 4-bromophenol analogously to Example 1a)), 0.67 g of palladium(II) acetate, 20.8 ml of triethylamine and 1.83 g of tri-o-tolylphosphine are heated to boiling in 225 ml of acetonitrile for 24 hours. After cooling to 0° C., the crystals are filtered off with suction and washed with acetonitrile and water. m.p.: 177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05536442 |
|---|
| Source dataset | uspto-grants-1996_07 |
|---|
| ORD ID | ord-ce435b02f4134d67baa6958b989a100f |
|---|
| Source note | uspto-grants-1996_07 |
|---|
