Hydrochloric Acid → (S)-2-[[(S)-2-(Hydroxy-2-(p-methoxyphenoxy)ethyl]-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide

Participants

Reaction Steps

4N Hydrochloric acid (1,4-dioxane solution, 50 ml) was added to (S)-1-(tert-butoxycarbonyl)-2-[1-hydroxy-2-(p-methoxyphenoxy)ethyl]pyrrolidine (8.03 g), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated and the residue was reacted, in the same manner as in Example 3-a), with N-(benzylaminocarbonyl)-L-proline obtained by stirring L-proline (2.63 g), benzyl isocyanate (2.58 g) and triethylamine (2.31 g) in DMF (25 ml) at room temperature for 1 hour to give the title compound (6.31 g).

Provenance & Evidence