反应详情

(S)-N-(Phenylmethyl)-2-[[(S)-2-[(phenylmethyloxy)acetyl]-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxamide (40.0 g) was dissolved in a mixed solvent of methanol (200 ml), water (40 ml) and acetic acid (20 ml). Palladium-black (4.0 g) was added and the mixture was stirred at room temperature under a hydrogen atmosphere for 3.5 hours. The catalyst in the reaction mixture was filtered off and the filtrate was concentrated to give the title compound (25.8 g).

1. filtrationThe catalyst in the reaction mixture was filtered off
2. concentrationthe filtrate was concentrated