Water → HCID 67745458, compound

Participants

Reaction Steps

N-(tert-Butoxycarbonyl)-L-proline (2.93 g), HOBt (4.55 g) and water-soluble carbodiimide hydrochloride (2.88 g) were added to a methylene chloride suspension (30 ml) of (S)-2-[1-hydroxy-2(phenylmethyloxy)ethyl]pyrrolidine (3.00 g) obtained in Example 5a), and the mixture was stirred at room temperature for 14 hours. The reaction mixture was washed with 5% citric acid, saturated sodium hydrogencarbonate and water in order, dried over anhydrous sodium sulfate, and concentrated to give the title compound (4.99 g).

Provenance & Evidence