1,4-Dioxane hydrochloride → HCID 67745406, compound

HRID 1735406Notes

Reaction equation

HRID 1735406 reaction equation
C(OC([N:8]1[CH2:30][CH2:29][CH2:28][C@H:9]1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH:17]([OH:27])[CH2:18][O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:11])=O)(C)(C)C.O1CCOCC1.[ClH:37]>>[ClH:37].[OH:27][CH:17]([C@@H:13]1[CH2:14][CH2:15][CH2:16][N:12]1[C:10](=[O:11])[C@@H:9]1[CH2:28][CH2:29][CH2:30][NH:8]1)[CH2:18][O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67745458HCID 67745458, compound

Product 1

HCID 67745406HCID 67745406, compound

Procedure

(S)-1-[N-(tert-Butoxycarbonyl)-L-prolyl]-2-[1-hydroxy-2(phenylmethyloxy)ethyl]pyrrolidine (4.99 g) was dissolved in a 3.6N hydrogen chloride-1,4-dioxane solution, and the mixture was left standing at room temperature for 40 minutes. The reaction mixture was concentrated to give the title compound (2.66 g). c) (S)-2-[[(S)-2-(1-Hydroxy-2-(phenylmethyloxy)ethyl]-1-pyrrolidinyl]carbonyl]-N-(2-phenylethyl)-1-pyrrolidinecarboxamide

Workup

  1. waitthe mixture was left
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-e81695dc84e444b28ca9353fc64ba29f
Source dataset
uspto-grants-1996_07
Patent number
US05536737

Reaction notes

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