Benzoyl chloride → HCID 53792042, compound

Participants

Reaction Steps

Benzoyl chloride (0.17 ml) was added to a pyridine solution (4.5 ml) of (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N-[(4-methylphenyl)methyl]-1-pyrrolidinecarboxamide (0.46 g) obtained in Example 10, and the mixture was stirred under ice-cooling for 4 hours. The reaction mixture was poured into saturated potassium hydrogensulfate and extracted with methylene chloride. The extract was washed with saturated sodium hydrogencarbonate and water in order, dried over anhydrous sodium sulfate, and concentrated to give the title compound (0.37 g) (see Table 2).

Provenance & Evidence