Hydrochloric Acid → HCID 54224371, compound

Participants

Reaction Steps

Acetic anhydride (0.42 ml) was added, under ice-cooling, to a pyridine solution (2.4 ml) of (S)-2-[[(S)-2-(hydroxyacetyl)1-pyrrolidinyl]carbonyl]-1-octanoylpyrrolidine (1.06 g) obtained in Example 14 and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into 1% hydrochloric acid and extracted with ethyl acetate. The extract was washed with 1% hydrochloric acid, water, saturated sodium hydrogencarbonate and water in order, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel column chromatography (eluent: chloroform-methanol) to give the title compound (1.02 g) (see Table 4).

Provenance & Evidence