Sodium Hydroxide → HCID 131719465, compound

Participants

Reaction Steps

1N Sodium hydroxide (45 ml) was dropwise added to a methanol solution (120 ml) of N-(benzyloxycarbonyl)-L-thioprolyl-L-proline methyl ester (11.84 g) under ice-cooling, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated and the residue was dissolved in water. The aqueous solution was acidified with concentrated hydrochloric acid under ice-cooling and extracted with chloroform. The extract was washed with water and concentrated to give the title compound (6.47 g).

Provenance & Evidence