Hydrochloric Acid → HCID 67745442, compound

Participants

Reaction Steps

4N Hydrochloric acid (1,4-dioxane solution, 50 ml) was added to (S)-1-(tert-butoxycarbonyl)-2-[2-(ethoxycarbonyl)-1-hydroxyethyl]pyrrolidine (5.73 g), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated to dryness and the residue was reacted with N-(benzylamincarbonyl)-L-proline obtained by stirring L-proline (1.15 g), benzyl isocyanate (1.13 g) and triethylamine (1.01 g) in DMF (10 ml), at room temperature for 1 hour, in the same manner as in Example 3-a), to give the title compound (3.36 g).

Provenance & Evidence