Dichloromethane → HCID 67745419, compound

Participants

Reaction Steps

Triethylamine (0.5 ml), 4-dimethylaminopyridine (20 mg) and tert-butyldimethylsilyl chloride (497 mg) were added to a methylene chloride solution (6 ml) of (S)-2-[[(S)-2-(1,3-dihydroxypropyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide (1.13 g), and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with chloroform, washed with saturated sodium hydrogencarbonate and saturated brine in order, dried over anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography (eluent: chloroform-methanol) to give the title compound (1.02 g).

Provenance & Evidence