Hydrochloric Acid → HCID 86749643, compound

Participants

Reaction Steps

N-[2(S)-(2(R)-(t-butoxycarbonylamino-3-triphenylmethyl mercaptopropylamino)-3(S)-methylpentyl]-N-methyl-isoleucyl-methionine methyl ester (0.19 g, 0.232 mmol, prepared as an intermediate in Example 5) was dissolved in MeOH (4 mL), treated with 1N NaOH soln (0.927 mL, 0.927 mmol), and stirred for 3.5 h at ambient temperature. The reaction mixture was concentrated, the residue dissolved in H2O (20 mL), neutralized with 1N HCl (0.927 mL, 0.927 mmol), and extracted with EtOAc (3×20 mL). The organic layers were combined, washed with brine, and dried (Na2SO4). Filtration and concentration to dryness gave 0.18g (96%) of the title compound which was used without further purification.

Provenance & Evidence