HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Spiro[1H-indene-1,4'-piperidin]-3(2H)-one trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 1'-(t-butyloxycarbonyl)-3,4-dihydro-3-oxospiro[1H-indene-1,4'-piperidine] | HCID 19030439 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Spiro[1H-indene-1,4'-piperidin]-3(2H)-one trifluoroacetamide | HCID 18467060 | — |
Reaction Steps
A solution of the intermediate from Step A in a 1:1:0.5 mixture of trifluoroacetic acid, dichloromethane and anisole was stirred for 1 hour and then concentrated and azeotroped from toluene to give the title compound. 1H NMR (200 MHz, CDCl3): 7.81-7.70 (m,l H), 7.62-7.45 (m, 2 H), 7.22-7.15 (m, 1 H), 3.72-3.58 (m,2 H), 3.29-3.04 (m, 2 H), 2.70 (s, 2 H), 2.47 (dt, 2 H), 1.85-1.75 (m, 2 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536716 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-a7735bce80bc49159c4585f086fbdfbc |
| Source note | uspto-grants-1996_07 |