Potassium Bromide → 7-Phenylacetamido-3-chloro-3-cephem-4-carboxylic acid

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Reaction Steps

The procedure described in Example 4 was repeated using p-nitrobenzyl 7-phenylacetamido-3-chloro-3-cephem-4-carboxylate as the starting material. The corresponding acid was obtained in 40.2% yield. M.p. 142°-145° C. IR (KBr) cm-1 : 3260, 1755, 1635, 1515, 680. NMR (DMSO-δ6) δ: 3.2-4.2 (m, 4 H, S--CH2 & Ar--CH2), 5.2 (d, 1 HS--CH), 5.7 (q, 1 H, N--CH), 7.3 (s, 5 H, Ar--H), 9.1 (d, 1 H, NH).

Provenance & Evidence