Hydrochloric Acid → HCID 23620956, compound

Participants

Reaction Steps

p-Nitrobenzyl 7-amino-3-chloro-3-cephem-4-carboxylate (10 gm) was suspended in a mixture of methanol (120 ml) and water (25 ml). Tin powder was charged at 30° C., followed by the addition of concentrated HCl (25 ml) in a methanol (20 ml) and water (5 ml) mixture over a period of 15 minutes. The reaction mixture was stirred for 1 hour. After completion of the reaction, aq. KHCO3 was added to bring the pH to 8.0, followed by the addition of activated carbon. After stirring for 10 minutes, the mixture was filtered. To the filtrate was added aq. HCl to bring the pH to 4.0. The product thus separated was filtered and dried. Yield: 3.9 g (68%).

Provenance & Evidence