4-Fluoro-alpha-(4-fluorophenyl)benzenemethanamine → HCID 15380272, compound

HRID 1735538Notes

Reaction equation

HRID 1735538 reaction equation
[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](=[O:30])SC2C=CC=CN=2)[CH:4]=1)#[N:2].[F:31][C:32]1[CH:46]=[CH:45][C:35]([CH:36]([NH2:44])[C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)=[CH:34][CH:33]=1>>[F:31][C:32]1[CH:33]=[CH:34][C:35]([CH:36]([NH:44][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:30])[C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)=[CH:45][CH:46]=1

Participants

3

Reactant 2

HCID 109550394-Fluoro-alpha-(4-fluorophenyl)benzenemethanamineHCID 15380265S-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylate

Product 1

HCID 15380272HCID 15380272, compoundYield 91%

Procedure

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 4,4'-difluorobenzhydrylamine (prepared as described in Preparation 12) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 91%.

Sources & evidence

ORD record
ord-a4d40484b28d41d68091f2e4cf97f8e7
Source dataset
uspto-grants-1996_07
Patent number
US05536714

Reaction notes

Loading…