Pyridine → 4-[(4-(Aminoiminomethyl)phenyl)amino]-4-oxobutanoic acid hydrochloride

HRID 1735633Notes

Reaction equation

HRID 1735633 reaction equation
[ClH:1].Cl.[NH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=N)=[CH:6][CH:5]=1.[C:13]1(=[O:19])[O:18][C:16](=[O:17])[CH2:15][CH2:14]1.[N:20]1C=CC=CC=1>>[ClH:1].[NH2:20][N:10]=[CH:8][C:7]1[CH:6]=[CH:5][C:4]([NH:3][C:13](=[O:19])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7922Succinic anhydrideHCID 756264-Aminobenzamidine dihydrochloride

Product 1

HCID 699519434-[(4-(Aminoiminomethyl)phenyl)amino]-4-oxobutanoic acid hydrochloride

Procedure

treating 4-aminobenzamidine dihydrochloride with succinic anhydride and pyridine in the presence of an aprotic solvent to give 4-[[4-(aminoiminomethyl)phenyl]amino]-4-oxobutanoic acid, monohydrochloride;

Sources & evidence

ORD record
ord-1251c4d7e26645b6ad4a68a057a04648
Source dataset
uspto-grants-1996_07
Patent number
US05536869

Reaction notes

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