Hydrochloric Acid → HCID 19433777, compound

Participants

Reaction Steps

24.6 g of potassium t-butoxide was dissolved in 200 ml of anhydrous THF under nitrogen. The solution was cooled with a dry ice bath to keep the inside temperature at -30° C. 4.9 g of compound (10) in 20 ml of THF was dropped into the solution and the mixture was stirred for 1 hour followed by warming to the room temperature. Then the reaction mixture was poused into ice, acidified with diluted hydrochloric acid and extracted with ether. After washing, drying and the solvent removal 3.5 g of liquid product was collected. MNR (CDCl3): δ 2.8 (m, 2H), 3.5 (t, 2H), 4.7-5.0 (m, 2H), 5.5-6.2 m, 1H), 7.2 (s, 1H), 8.1 (s, 2H) ppm.

Provenance & Evidence