2-Dimethylaminopyridine → HCID 15280160, compound

Participants

Reaction Steps

16.7 g of 5-amino-4-isothiocyanato-3-methylisothiazole and 0.5 g of dimethylaminopyridine are dissolved in a mixture of 100 ml of toluene and 100 ml of pyridine, and 15.9 g of pivaloyl chloride are added. Stirring is carried out for 16 hours at 80° C., the solution is evaporated to dryness, the residue is taken up in ethyl acetate and the solution is extracted with aqueous sodium bicarbonate solution and 10% strength hydrochloric acid. The organic phase is dried and evaporated down.

Provenance & Evidence