Potassium thiocyanate → 5-Amino-3-methyl-4-isothiazolyl thiocyanate

HRID 1735689Notes

Reaction equation

HRID 1735689 reaction equation
[CH3:1][C:2]1[C:6](Br)=[C:5]([NH2:8])[S:4][N:3]=1.[C:9]([S-:11])#[N:10].[K+]>CO>[CH3:1][C:2]1[C:6]([S:11][C:9]#[N:10])=[C:5]([NH2:8])[S:4][N:3]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 177499314-Bromo-3-methyl-1,2-thiazol-5-amine

Product 1

HCID 146188855-Amino-3-methyl-4-isothiazolyl thiocyanate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

386 g of 3-methyl-4-bromo-5-aminoisothiazole and 200 g of KSCN in methanol are refluxed for 6 hours. The product crystallizes out on cooling. 800 ml of water are added and the product is filtered off under suction and washed with water.

Workup

  1. customThe product crystallizes out
  2. temperatureon cooling
  3. addition800 ml of water are added
  4. filtrationthe product is filtered off under suction
  5. washwashed with water

Sources & evidence

ORD record
ord-7f6a56f2abef48c7b73daed48f3895b6
Source dataset
uspto-grants-1996_07
Patent number
US05538939

Reaction notes

Loading…