p-Toluenesulfonic acid → HCID 10421644, compound

Participants

Reaction Steps

A solution of 18 g of 1-(2-bromophenyl)-1,4-pentanedione and 1 g of p-toluenesulfonic acid in 200 ml of anhydrous benzene is heated under reflux over molecular sieves for 12 h. The resulting solution is washed 3 times with brine, dried over Na2SO4 and evaporated to dryness under reduced pressure. The residue is purified by FC (eluent hexane:acetate 95:5) and 12.2 of a light yellow oil are obtained g (70% yield). 1H NMR (CDCl3), δ: 2.38 (d, 3 H), 6.12 (m, 1 H), 7.1-7.4 (m, 3 H), 7.63 (dd, 1 H), 7.79 (dd, 1 H).

Provenance & Evidence