p-Toluenesulfonic acid → HCID 10398395, compound

Participants

Reaction Steps

A solution of 10.8 g of methyl 2,3-epoxy-3-(4-methylphenyl)-5,5-dimethoxypentanoate and 1.1 g of p-toluenesulfonic acid in 60 ml of anhydrous benzene is refluxed over molecular sieves for 3 h. 60 ml of ethyl acetate are added, the mixture is washed 2 times with 50 ml of a NaHCO3 saturated aqueous solution, dried over Na2SO4 and the solvent is evaporated under reduced pressure. The residue is purified by F.C. to obtain 4.2 g of a yellow oil (50% yield). 1H NMR (CDCl3), δ: 2.39 (s, 3 H), 3.85 (s, 3 H), 6.62 (d, 1 H), 7.24 (d, 2 H), 7.48 (d, 2 H), 7.56 (d, 1 H).

Provenance & Evidence