Potassium Carbonate → HCID 19434458, compound

Participants

Reaction Steps

A mixture of 4.5 g of 2-butyl-4-chloro-5-formylimidazole and 6.75 g of K2CO3 in 200 ml of anhydrous DMF under nitrogen atmosphere is added under stirring with a solution of 8.1 g of methyl 4'-bromomethyl-1,1'-biphenyl-2-carboxylate in 10 ml of anhydrous DMF. The mixture is stirred at room temperature for 2 hours then concentrated under reduced pressure to 50 ml, poured into 500 ml of H2O and extracted with CH2Cl2. The organic phase is washed with H2O, dried over Na2SO4 and evaporated to dryness under reduced pressure. 9 of an orange oil are obtained which is used without further purification. 1H NMR (CDCl3), δ: 0.89 (t, 3 H); 1.45 (m, 2 H); 1.72 (m, 2 H); 2.66 (m, 2 H); 3.62 (s, 3 H); 5.59 (s, 2 H); 7.02-7.88 (m, 8 H); 9.76 (s, 1 H).

Provenance & Evidence